Hydrochloric Acid → HCID 19915159、化合物

HRID 1651588ノート

反応式

HRID 1651588 の反応式
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([CH:9]2[CH2:13][CH2:12][CH:11]([N:14]3C(=O)C4C(=CC=CC=4)C3=O)[CH2:10]2)=[C:4]([F:25])[CH:3]=1.[ClH:26]>C(O)C>[ClH:26].[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([CH:9]2[CH2:13][CH2:12][CH:11]([NH2:14])[CH2:10]2)=[C:4]([F:25])[CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 14770834HCID 14770834、化合物

生成物 1

HCID 19915159HCID 19915159、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A solution of 20.3 g (50 mmol) of 2-[3-(4-bromo-2,5-difluorophenyl)cyclopentyl]-1H-isoindole-1,3-(2H)-dione in 100 ml of concentrated hydrochloric acid and 100 ml of ethanol was heated at reflux for 4 hours. The ethanol was allowed to evaporate and the aqueous acid mixture was heated at reflux for 4 additional hours. The solution was filtered through a fiber glass pad to remove some insoluble material and the filtrate was evaporated in vacuo. The residue was triturated with ethanol which was also removed in vacuo to give 13.1 g of the title compound.

後処理

  1. temperatureat reflux for 4 hours
  2. customto evaporate
  3. temperaturethe aqueous acid mixture was heated
  4. temperatureat reflux for 4 additional hours
  5. filtrationThe solution was filtered through a fiber glass pad
  6. customto remove some insoluble material
  7. customthe filtrate was evaporated in vacuo
  8. customThe residue was triturated with ethanol which
  9. customwas also removed in vacuo

出典と根拠

ORDレコード
ord-85d66fb64edc430796a6ef044442031b
出典データセット
uspto-grants-1990_05
特許番号
US04929613

反応ノート

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