HCID 14770861、化合物 → HCID 67916341、化合物

HRID 1651592ノート

反応式

HRID 1651592 の反応式
C([NH:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:28])[C:15]([C:23]([O:25]CC)=[O:24])=[CH:16][N:17]3[CH:20]3[CH2:22][CH2:21]3)=[CH:12][C:11]=2[F:29])[CH2:6]1)(=O)C.[ClH:30].C(O)C>>[ClH:30].[NH2:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:28])[C:15]([C:23]([OH:25])=[O:24])=[CH:16][N:17]3[CH:20]3[CH2:21][CH2:22]3)=[CH:12][C:11]=2[F:29])[CH2:6]1

参加物

3

反応物 2

HCID 14770861HCID 14770861、化合物HCID 21887872Ethanol hydrochloride

生成物 1

HCID 67916341HCID 67916341、化合物

実験手順

A mixture of 20.0 g (50 mmol) of 7-[3-(acetylamino) cyclopentyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, ethyl ester was heated in a mixture of 6.0 M hydrochloric acid/ethanol (20 ml/150 ml) at reflux for 8 hours. The solvent was removed in vacuo and the residue slurried in 200 ml of water and filtered. The filtrate was evaporated in vacuo and the residue triturated in ethanol and filtered. The precipitate was washed with ethanol, ether, and dried in vacuo to give 13.6 g of the title compound.

後処理

  1. temperatureat reflux for 8 hours
  2. customThe solvent was removed in vacuo
  3. filtrationfiltered
  4. customThe filtrate was evaporated in vacuo
  5. customthe residue triturated in ethanol
  6. filtrationfiltered
  7. washThe precipitate was washed with ethanol, ether
  8. customdried in vacuo

出典と根拠

ORDレコード
ord-e93c26385c0f45478f7ca3633c9527e9
出典データセット
uspto-grants-1990_05
特許番号
US04929613

反応ノート

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