Aluminum → Benzamide, N-(4-amino-5-chloro-2-hydroxyphenyl)-

HRID 1651748

反応式

HRID 1651748 の反応式
[Al].[C:2]([NH:10][C:11]1[CH:16]=[C:15]([Cl:17])[C:14]([N+:18]([O-])=O)=[CH:13][C:12]=1[OH:21])(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>[Co].[Cr].[Ni]>[NH2:18][C:14]1[C:15]([Cl:17])=[CH:16][C:11]([NH:10][C:2](=[O:9])[C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)=[C:12]([OH:21])[CH:13]=1

参加物

6

反応物 2

HCID 5359268AluminumHCID 5483228Benzamide, N-(5-chloro-2-hydroxy-4-nitrophenyl)-

生成物 1

HCID 78779Benzamide, N-(4-amino-5-chloro-2-hydroxyphenyl)-

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 23976Chromium触媒HCID 104730Cobalt触媒2 回

実験手順

Using the procedure described above and 5.0 g of a chromium-containing Raney cobalt catalyst containing about 20-30 weight percent aluminum, 1.5 to 2.5 weight percent nickel and the remainder cobalt, 2-benzamido 4-chloro 5-nitrophenol is hydrogenated for a total of 4 hours to obtain the corresponding amine, 5-amino 2-benzamido 4-chlorophenol. Analysis of a sample of the reaction mixture taken and analyzed in accordance with the procedure used in the preceding example, show that the purity of the product is 98.4 percent and the presence of 0.1 percent of dechlorinated by product. The azo, azoxy and hydroxylamine intermediate products are soluble in the final filtrate and thus are easily removed from the product. No starting material is detected.

後処理

  1. customis hydrogenated for a total of 4 hours

出典と根拠

ORDレコード
ord-c7ba2b9b250d4e90b4c69e31f0088994
出典データセット
uspto-grants-1990_05
特許番号
US04929737

関連ノート

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