Ethyl 4-amino-4-(3-methoxyphenyl)butanoate → 5-(3-Methoxyphenyl)-2-pyrrolidinone

HRID 1654005ノート

反応式

HRID 1654005 の反応式
[NH2:1][CH:2]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=1)[CH2:3][CH2:4][C:5](OCC)=[O:6]>C1(C)C=CC=CC=1>[CH3:17][O:16][C:12]1[CH:11]=[C:10]([CH:2]2[NH:1][C:5](=[O:6])[CH2:4][CH2:3]2)[CH:15]=[CH:14][CH:13]=1

参加物

3

反応物 1

HCID 23361303Ethyl 4-amino-4-(3-methoxyphenyl)butanoate

生成物 1

HCID 152932255-(3-Methoxyphenyl)-2-pyrrolidinone収率 90%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Ethyl 4-amino-4-(3-methoxyphenyl)butanoate (9.39 g) was dissolved in toluene (50 ml) and the solution heated under reflux for 0.5 hr to 1.0 hr. The mixture was cooled to ambient temperature, the precipitate was collected, and the filtrate was concentrated. The residue was recrystallized from ether to give 6.80 g (90%) of product, mp 84°-85° C.

後処理

  1. temperaturethe solution heated
  2. temperatureunder reflux for 0.5 hr to 1.0 hr
  3. customthe precipitate was collected
  4. concentrationthe filtrate was concentrated
  5. customThe residue was recrystallized from ether

出典と根拠

ORDレコード
ord-20fa95ce25ee4dce90aa29731dd28832
出典データセット
uspto-grants-1995_04
特許番号
US05405845

反応ノート

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