Water → 2-Bromo-1-(2,4-difluorophenyl)propan-1-one

HRID 1654180

反応式

HRID 1654180 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][CH3:11].[Br:13]Br.O>C(Cl)Cl>[Br:13][CH:10]([CH3:11])[C:9]([C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[F:1])=[O:12]

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 1235862',4'-Difluoropropiophenone

生成物 1

HCID 110758302-Bromo-1-(2,4-difluorophenyl)propan-1-one収率 98.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In methylene chloride (300 ml) was dissolved 2',4'-difluoropropiophenone (55 g), to which was added bromine (50 g) dropwise, while stirring, during 30 minutes. The mixture was stirred for 30 minutes at room temperature. To the reaction mixture was added water (200 ml), and the methylene chloride layer was washed three times, followed by drying over anhydrous magnesium sulfate. The solvent was distilled off to leave 2-bromo-2',4'-difluoropropiophenone (77 g) as a pale yellow oily product.

後処理

  1. stirringThe mixture was stirred for 30 minutes at room temperature
  2. washthe methylene chloride layer was washed three times
  3. dry with materialby drying over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-7b5b9527b2b84a238e79ed329f9e217c
出典データセット
uspto-grants-1995_04
特許番号
US05405861

関連ノート

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