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Benzaldehyde → 1-Phenyl-3-(trimethylsilyl)-2-propyn-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Trimethylsilylacetylene | HCID 66111 | — |
| 反応物 | Lithium bis(trimethylsilyl)amide | HCID 57426343 | — |
| 反応物 | HCID 178462446 | HCID 178462446 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-Phenyl-3-(trimethylsilyl)-2-propyn-1-ol | HCID 2760416 | — |
反応手順
In step a, trimethylsilylacetylene (1) can first be reacted with a non-nucleophilic base, such as lithium hexamethyldisilazane, in a suitable aprotic solvent, such as tetrahydrofuran. The resulting lithium acetylide can then be reacted with the appropriate benzaldehyde compound of structure 2 to give the corresponding α-[(trimethylsilyl)ethynyl]-benzenemethanol compound of structure 3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05409942 |
| 出典データセット | uspto-grants-1995_04 |
| ORD ID | ord-a4bd6d5991e44ca787171a8d519a9802 |
| 出典メモ | uspto-grants-1995_04 |