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Dichloromethane → 1-Phenyl-3-(2-furanyl)-2-propyne-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Cornforth reagent | HCID 2724130 | — |
| 反応物 | alpha-[(2-Furanyl)ethynyl]-benzenemethanol | HCID 20076917 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-Phenyl-3-(2-furanyl)-2-propyne-1-one | HCID 14401734 | — |
反応手順
Place pyridinium dichromate (0.75 g, 2 mmol) and methylene chloride (15 mL) under argon atmosphere and cool to 0° C. Add α-[(2-furanyl)ethynyl]-benzenemethanol (297 mg, 1.5 mmol). Stir overnight while slowly warming to room temperature. Dilute with ethyl ether and filter the chromium salts. Purify by silica gel chromatography to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05409942 |
| 出典データセット | uspto-grants-1995_04 |
| ORD ID | ord-a42f66b7f987487399e9614f7813cf37 |
| 出典メモ | uspto-grants-1995_04 |