2-Amino-3-(2-fluorobenzyloxy)pyridine → N'-[3-[(2-fluorophenyl)methoxy]-2-pyridinyl]-2-phenylethanimidamide;hydrochloride

HRID 1654848ノート

反応式

HRID 1654848 の反応式
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:16])=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:17].[C:18]1([CH2:24][C:25](=[NH:29])OCC)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[ClH:17].[F:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:9][O:8][C:7]1[C:2]([NH:1][C:25](=[NH:29])[CH2:24][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 102424912-Amino-3-(2-fluorobenzyloxy)pyridineHCID 12218775Ethyl 2-phenylacetimidate hydrochloride

生成物 1

HCID 178479194N'-[3-[(2-fluorophenyl)methoxy]-2-pyridinyl]-2-phenylethanimidamide;hydrochloride収率 4.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-amino-3-(2-fluorobenzyloxy)pyridine (4.36 g, 20 mmol) and ethyl phenylacetimidate hydrochloride (4.39 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave an oil which was purified by flash chromatography (chloroform/methanol) and recrystallisation from ethanol/ether to obtain the product (0.36 g), m.p. 160°-165° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customEvaporation of the solvent
  4. customgave an oil which
  5. customwas purified by flash chromatography (chloroform/methanol) and recrystallisation from ethanol/ether

出典と根拠

ORDレコード
ord-0879767a7f5846faa26d135f01156aab
出典データセット
uspto-grants-1995_04
特許番号
US05409943

反応ノート

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