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Water → 2-Amino-3-(2,6-difluorobenzyloxy)-6-methylpyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Amino-6-methylpyridin-3-ol | HCID 88500 | — |
| 反応物 | 2-(Bromomethyl)-1,3-difluorobenzene | HCID 581435 | — |
| 触媒 | Trioctylmethylammonium chloride | HCID 21218 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 2-Amino-3-(2,6-difluorobenzyloxy)-6-methylpyridine | HCID 20077021 | 94% |
反応手順
A mixture of 2,6-difluorobenzyl bromide (25 g, 0.12 1 mol) and 2-amino-3-hydroxy-6methylpyridine (13.6 g, 0.11 mol) in 40% aqueous sodium hydroxide solution (200 ml) and dichloromethane (200 ml) was treated with Adogen 464 (10 ml) and stirred vigorously at room temperature for 16 hours. A further 200 ml of water was added and the product extracted into dichloromethane, dried, and the solvent evaporated to obtain the product (25.8 g, 94%), m.p. 121°-123° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05409943 |
| 出典データセット | uspto-grants-1995_04 |
| ORD ID | ord-e35093c0a8ae4c0ea8cb0e692c40495f |
| 出典メモ | uspto-grants-1995_04 |