Toluene → N-[3-(2-chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-4-methylphenylthiourea

HRID 1654895

反応式

HRID 1654895 の反応式
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:17])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]=[C:26]=[S:27])=[CH:21][CH:20]=1.C1(C)C=CC=CC=1>CCOCC>[Cl:17][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]([F:16])[C:10]=1[CH2:9][O:8][C:7]1[C:2]([NH:1][C:26]([NH:25][C:22]2[CH:23]=[CH:24][C:19]([CH3:18])=[CH:20][CH:21]=2)=[S:27])=[N:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 1140TolueneHCID 12149p-Tolyl isothiocyanateHCID 101062702-Amino-3-(2-chloro-6-fluorobenzyloxy)pyridine

生成物 1

HCID 20076981N-[3-(2-chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-4-methylphenylthiourea

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 2-amino-3-(2-chloro-6-fluorobenzyloxy)pyridine (2g, 0.008 mol), 4methylphenyl isothiocyanate (1.43g, 0.0096 mol) and toluene (10 ml) was heated under reflux for 5 hours, then cooled and diluted with ether to induce crystallisation of the product. Yield 2.61g (82%) m.p. 138°-140 ° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. temperaturecooled
  4. customcrystallisation of the product

出典と根拠

ORDレコード
ord-599005b0501a4dc7bc0d9d1544590ab3
出典データセット
uspto-grants-1995_04
特許番号
US05409943

関連ノート

読み込み中…