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Toluene → N-[3-(2-Chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-(2-methyl-4chlorophenyl)thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | 3-Chloro-6-isothiocyanatotoluene | HCID 90021 | — |
| 反応物 | 2-Amino-3-(2-chloro-6-fluorobenzyloxy)pyridine | HCID 10106270 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | N-[3-(2-Chloro-6-fluorobenzyloxy)pyrid-2-yl]-N'-(2-methyl-4chlorophenyl)thiourea | HCID 20076993 | — |
反応手順
A mixture of 2-amino-3-(2-chloro-6-fluorobenzyloxy)pyridine (2 g, 0.008 mol), (2-methyl-4-chlorophenyl isothiocyanate (1.76 g, 0.0096 mol) and toluene (10 ml) was heated under reflux for 5 hours, then cooled and diluted with ether to induce crystallisation of the product. Yield 2.72g (77%), m.p. 176°-177 ° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05409943 |
| 出典データセット | uspto-grants-1995_04 |
| ORD ID | ord-0d0639210ed94f608b1871b9a829d93e |
| 出典メモ | uspto-grants-1995_04 |