Ammonia → HCID 178512028、化合物

HRID 1654915ノート

反応式

HRID 1654915 の反応式
[F:1][C:2]1[C:26]([F:27])=[CH:25][CH:24]=[C:23]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[NH3:29]>>[F:1][C:2]1[C:26]([F:27])=[CH:25][CH:24]=[C:23]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[NH:29])=[N:8][CH:9]=[CH:10][CH:11]=1

参加物

3

反応物 2

HCID 222AmmoniaHCID 20077029N-(3-(2,3,6-Trifluorobenzyloxy)pyrid-2-yl)-N'-(4-chlorophenyl)thiourea

生成物 1

HCID 178512028HCID 178512028、化合物

実験手順

A mixture of yellow mercuric oxide (1.23g, 0,056 mol), N-[3-(2,3,6-trifluorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea (2.00g 0.0047mol) and methanolic ammonia solution (40 ml) was stirred for 1 day at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent, trituration with ether and recrystallisation from acetonitrile gave the desired product. Yield 1.20 g (63%), m.p. 153°-156 ° C.

後処理

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent, trituration
  4. customwith ether and recrystallisation from acetonitrile

出典と根拠

ORDレコード
ord-5551d158a425474696bcc91636298605
出典データセット
uspto-grants-1995_04
特許番号
US05409943

反応ノート

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