Toluene → HCID 20076938、化合物

HRID 1654928ノート

反応式

HRID 1654928 の反応式
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:17])=[CH:6][C:5]([Cl:18])=[CH:4][N:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[S:28])=[CH:22][CH:21]=1.C1(C)C=CC=CC=1>CCOCC>[Cl:17][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]([F:16])[C:10]=1[CH2:9][O:8][C:7]1[C:2]([NH:1][C:27]([NH:26][C:23]2[CH:24]=[CH:25][C:20]([Cl:19])=[CH:21][CH:22]=2)=[S:28])=[N:3][CH:4]=[C:5]([Cl:18])[CH:6]=1

参加物

5

反応物 3

HCID 1140TolueneHCID 164804-Chlorophenyl isothiocyanateHCID 200770602-Amino-3-(2-chloro-6-fluorobenzyloxy)-5-chloropyridine

生成物 1

HCID 20076938HCID 20076938、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 2-amino-3-(2-chloro-6-fluorobenzyloxy)-5-chloropyridine (0.82 g, 0.0028 mol), 4-chlorophenyl isothiocyanate (0.56 g, 0.0033 mol) and toluene (10 ml) was heated under reflux for 16 hours, then cooled and diluted with ether to induce crystallisation of the product, which was triturated with ethanol. Yield 0.68 g (54%), m.p. 158°-160 ° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 16 hours
  3. temperaturecooled
  4. customcrystallisation of the product, which
  5. customwas triturated with ethanol

出典と根拠

ORDレコード
ord-1f23fc8c37ec40be860f58665ec56d7b
出典データセット
uspto-grants-1995_04
特許番号
US05409943

反応ノート

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