Ammonia → HCID 178512030、化合物

HRID 1654929ノート

反応式

HRID 1654929 の反応式
[Cl:1][C:2]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:13][C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=S)=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1.[NH3:29]>>[Cl:1][C:2]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:13][C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[NH:29])=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1

参加物

3

反応物 2

HCID 222AmmoniaHCID 20076938HCID 20076938、化合物

生成物 1

HCID 178512030HCID 178512030、化合物

実験手順

A mixture of yellow men:uric oxide (0.36 g, 0.0017 mol), N-[3-(2-chloro-6-fluorobenzyloxy)-5-chloropyrid-2-yl]-N'-4-chlorophenylthiourea (0.64 g, 0.0014 mol)and methanolic ammonia solution (20 ml) was stirred for 1 day at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by recrystallisation from ethanol gave the desired product. Yield 0.09 g (15%), m.p. 162°-163 ° C.

後処理

  1. additionA mixture of yellow men
  2. customThe solvent was removed in vacuo
  3. filtrationfiltered hot
  4. customEvaporation of the solvent
  5. customfollowed by recrystallisation from ethanol

出典と根拠

ORDレコード
ord-3507b44652704b43a0079b336444d124
出典データセット
uspto-grants-1995_04
特許番号
US05409943

反応ノート

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