Methylamine → N-(3-(2,6-Dichlorobenzyloxy)pyrid-2-yl)-N'-methyl-N"-(4-chlorophenyl)guanidine

HRID 1654933ノート

反応式

HRID 1654933 の反応式
[Cl:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=S)=[N:8][CH:9]=[CH:10][CH:11]=1.[CH3:28][NH2:29]>>[Cl:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:12][C:13]([NH:29][CH3:28])=[N:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[N:8][CH:9]=[CH:10][CH:11]=1

参加物

3

反応物 2

HCID 6329MethylamineHCID 20076936N-[3-(2,6-dichlorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea

生成物 1

HCID 178484918N-(3-(2,6-Dichlorobenzyloxy)pyrid-2-yl)-N'-methyl-N"-(4-chlorophenyl)guanidine

実験手順

A mixture of N-[3-(2,6-dichlorobenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea (2.0 g, 0.0045 mol), yellow mercuric oxide (1.18 g, 0.0054 mol) and 33% w/w methylamine in methylated spirit (40 ml) was stirred at room temperature for 24 hours. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent and recrystallisation from acetonitrile gave the desired product. Yield 1.53 g (78%), m.p. 153°-156 ° C.

後処理

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered hot
  3. customEvaporation of the solvent and recrystallisation from acetonitrile

出典と根拠

ORDレコード
ord-4da485ca7b2d4713b1b2f335c443f208
出典データセット
uspto-grants-1995_04
特許番号
US05409943

反応ノート

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