Acetyl chloride → HCID 20077196、化合物

HRID 1654951ノート

反応式

HRID 1654951 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[CH3:5][O:6][C:7](=[O:18])[CH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1.[C:19](Cl)(=[O:21])[CH3:20]>C(Cl)Cl>[CH3:5][O:6][C:7](=[O:18])[CH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:19](=[O:21])[CH3:20])[CH:15]=2)[CH2:10]1

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 14090225Methyl (2,3-dihydro-1H-inden-2-yl)acetate

生成物 1

HCID 20077196HCID 20077196、化合物収率 91%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

160 ml of methylene chloride was added with 52.9 g (0.388 mol) of anhydrous aluminum chloride, and further added with 40 ml of methylene chloride containing 25.03 g (0.132 mol) of methyl(indan-2-yl)acetate under ice-cooling. Subsequently, 13.1 ml (0.185 mol) of acetyl chloride was added thereto dropwise. Stirring was conducted for 40 minutes at the same temperature. The reaction mixture was poured into ice-water and the organic phase was collected. After washing and drying, the solvent was condensed under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:2) to obtain 27.8 g of an oily product. Yield: 91%

後処理

  1. temperaturecooling
  2. customthe organic phase was collected
  3. washAfter washing
  4. customdrying
  5. customcondensed under reduced pressure
  6. customthe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:2)

出典と根拠

ORDレコード
ord-11aa938d732b4e16bbe408595e14c20b
出典データセット
uspto-grants-1995_04
特許番号
US05409956

反応ノート

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