Hydrochloric Acid → 3,4-Dibenzyloxyphenylacetonitrile

HRID 1655033ノート

反応式

HRID 1655033 の反応式
[OH:1][C:2]1[C:7](O)=[CH:6][C:5]([CH2:9][C:10]#[N:11])=[CH:4][CH:3]=1.[C:12](=[O:15])([O-])[O-].[K+].[K+].[CH2:18](Cl)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.Cl>CN(C)C=O.O>[CH2:18]([O:1][C:2]1[C:7]([O:15][CH2:12][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:6][C:5]([CH2:9][C:10]#[N:11])=[CH:4][CH:3]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 109097272-(3,4-Dihydroxyphenyl)acetonitrile

生成物 1

HCID 27580313,4-Dibenzyloxyphenylacetonitrile

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture consisting of one mole (149 g) of 4,5-dihydroxyphenylacetonitrile prepared in stage 1, two moles of potassium carbon ate (276 g) and 2.2 moles (278,5 g) of benzyl chloride in 745 ml of dimethylformamide is heated to 105°-110° C. for approximately 30 minutes. At the end of the reaction, the reaction mixture is diluted with 2.5 kg of a mixture of ice and water, and is neutralized with hydrochloric ac id while being briskly stirred, The expected product, which has precipitated, is filtered off, washed with water, and is again mixed into a paste with ethanol and then with isopropyl ether.

後処理

  1. temperatureis heated to 105°-110° C. for approximately 30 minutes
  2. customAt the end of the reaction
  3. customThe expected product, which has precipitated
  4. filtrationis filtered off
  5. washwashed with water
  6. additionis again mixed into a paste with ethanol

出典と根拠

ORDレコード
ord-08955e05d8bd487ba860380434e72499
出典データセット
uspto-grants-1995_04
特許番号
US05410067

反応ノート

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