Indole → methyl 2-(1H-indol-1-yl)acetate

HRID 1655062ノート

反応式

HRID 1655062 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.Br[CH2:11][C:12]([O:14][CH3:15])=[O:13]>>[CH3:15][O:14][C:12](=[O:13])[CH2:11][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

参加物

3

反応物 2

HCID 798IndoleHCID 60984Methyl bromoacetate

生成物 1

HCID 966836methyl 2-(1H-indol-1-yl)acetate

実験手順

This compound was prepared from indole and methyl bromoacetate by the method described in Example 10, part i. The reaction mixture was worked up by concentrating in vacuo, diluting with water and extracting with ethyl acetate (3x). The combined extracts were washed with water (3x) and brine, dried and evaporated to an oil. The residue was purified by chromatography on flash silica eluting with petroleum spirit 40°-60° C.--diethyl ether (5:1, 2:1) to give the product.

後処理

  1. concentrationby concentrating in vacuo
  2. additiondiluting with water
  3. extractionextracting with ethyl acetate (3x)
  4. washThe combined extracts were washed with water (3x) and brine
  5. customdried
  6. customevaporated to an oil
  7. customThe residue was purified by chromatography on flash silica eluting with petroleum spirit 40°-60° C.
  8. customdiethyl ether (5:1, 2:1) to give the product

出典と根拠

ORDレコード
ord-ae578bbd2dcd4899a9911b36c06ae63a
出典データセット
uspto-grants-1995_04
特許番号
US05410061

反応ノート

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