p-Toluenesulfonic acid monohydrate → 2-Chlororesorcinol

HRID 1655092

反応式

HRID 1655092 の反応式
[Cl:1][C:2]1[C:8]([OH:9])=[C:7](C(C)(C)C)[CH:6]=[C:5](C(C)(C)C)[C:3]=1[OH:4].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Cl:1][C:2]1[C:8]([OH:9])=[CH:7][CH:6]=[CH:5][C:3]=1[OH:4]

参加物

3

反応物 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 15276826HCID 15276826、化合物

生成物 1

HCID 803312-Chlororesorcinol収率 91%

反応条件

温度
210 °C

実験手順

A mixture of 2-chloro-4,6-di-tert-butylresorcinol (25.7 g, 100 mmol, prepared as described in Example 1A) and p-toluenesulfonic acid monohydrate (0.2 g, 1 mmol) is added to a flask--which is equipped with a gas withdrawing port leading to a dry ice cooled trap--heated at 210° C. for 2 hours, then allowed to cool. Recrystallization from toluene affords pure 2-chlororesorcinol (13.2-13.9 g, 91-96% yield). The yield of recovered isobutylene is >95%.

後処理

  1. additionis added to a flask
  2. customwhich is equipped with a gas
  3. customwithdrawing port
  4. customleading to a dry ice cooled trap
  5. temperatureto cool
  6. customRecrystallization from toluene

出典と根拠

ORDレコード
ord-0d2cb727bc624c9daa408a04e161c125
出典データセット
uspto-grants-1995_04
特許番号
US05410083

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