Water → HCID 22000390、化合物
反応式
[Br:1]Br.[F:3][C:4]1[CH:15]=[CH:14][C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][C:12](=[O:13])[C:6]=2[CH:5]=1.O>CCOCC>[F:3][C:4]1[CH:15]=[CH:14][C:7]2[CH2:8][CH2:9][CH2:10][CH:11]([Br:1])[C:12](=[O:13])[C:6]=2[CH:5]=1参加物
5
実験手順
68.9 g of bromine are added dropwise to a solution of 73.1 g of 3-fluoro-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one in 700 ml of ether under ice-cooling during 1 hour. After the mixture is stirred for 1 hour, the reaction mixture is poured into water and the mixture is extracted with ether. The ether layer is washed, dried and evaporated to remove the solvent to obtain 106.8 g of 3-fluoro-6-bromo-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one as an oil.
後処理
- temperaturecooling during 1 hour
- extractionthe mixture is extracted with ether
- washThe ether layer is washed
- customdried
- customevaporated
- customto remove the solvent
出典と根拠
- ORDレコード
- ord-56d5bea59b6b4a358569d60802d13f7c
- 出典データセット
- uspto-grants-1993_10
- 特許番号
- US05252589
反応ノート
読み込み中…