Methanesulfonyl chloride → 1-Propanol, 3-(trimethylsilyl)-

HRID 1655989ノート

反応式

HRID 1655989 の反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH3:6][Si:7]([CH3:13])([CH3:12])[CH2:8][CH2:9][CH2:10][OH:11]>ClCCl>[CH3:6][Si:7]([CH3:13])([CH3:12])[CH2:8][CH2:9][CH2:10][OH:11].[CH3:1][S:2]([O-:4])(=[O:11])=[O:3]

参加物

5

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 762131-Propanol, 3-(trimethylsilyl)-

生成物 2

HCID 762131-Propanol, 3-(trimethylsilyl)-HCID 85257Methanesulfonate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Methanesulfonylchloride (0.73 ml, 9 mmol) was added dropwise to a solution of 3-(trimethylsilyl)-1-propanol (1.2 ml, 7.56 mmol) cooled at 0° C. in 20 ml of dichloromethane. After 45 minutes stirring, the reaction mixture was partitioned between water and dichloromethane, the organic phase was separated, the solvent was evaporated under reduced pressure to afford the expected 3-(trimethylsilyl)-1-propanol, methanesulfonate in crude quantitative yield.

後処理

  1. customthe reaction mixture was partitioned between water and dichloromethane
  2. customthe organic phase was separated
  3. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-7b4c312d11d74f4395c712f71157cdbd
出典データセット
uspto-grants-1993_10
特許番号
US05252587

反応ノート

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