2,2-Dimethoxypropane → Methyl 1,2,3,4-tetrahydronaphthalene-2-carboxylate

HRID 1656044

反応式

HRID 1656044 の反応式
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[C:11]([OH:13])=[O:12].[CH3:14]OC(OC)(C)C>CO>[C:11]([CH:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:1]1)([O:13][CH3:14])=[O:12]

参加物

4

反応物 2

HCID 64952,2-DimethoxypropaneHCID 1013701,2,3,4-Tetrahydro-2-naphthoic acid

生成物 1

HCID 12588372Methyl 1,2,3,4-tetrahydronaphthalene-2-carboxylate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
5 °C

実験手順

Dissolve 1,2,3,4-tetrahydro-2-naphthoic acid (10 g, 57 mmol) in methanol (100 mL) and add dimethoxypropane (3 mL). Cool to 5° C. and saturate with hydrogen chloride gas. Allow to stand overnight then evaporate the solvent in vacuo. Take the residue up in ethyl ether, wash with saturated sodium hydrogen carbonate and dry (MgSO4). Evaporate the solvent in vacuo and distill to give 2-carbomethoxy-1,2,3,4-tetrahydronaphthalene; bp 90°-96° [email protected] mm Hg).

後処理

  1. concentrationsaturate with hydrogen chloride gas
  2. customthen evaporate the solvent in vacuo
  3. washwash with saturated sodium hydrogen carbonate
  4. dry with materialdry (MgSO4)
  5. customEvaporate the solvent in vacuo
  6. distillationdistill

出典と根拠

ORDレコード
ord-468bb5f1f93a4377951a1538f2606c3e
出典データセット
uspto-grants-1993_10
特許番号
US05252601

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