1-(3-Chlorophenyl)piperazine → HCID 19787740、化合物
反応式
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:4][C:3]=1[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[Cl:21][C:22]1[CH:23]=[C:24]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:25]=[CH:26][CH:27]=1>C(O)CCC>[C:8]1([C:5]2[N:6]=[N:7][C:2]([N:31]3[CH2:30][CH2:29][N:28]([C:24]4[CH:25]=[CH:26][CH:27]=[C:22]([Cl:21])[CH:23]=4)[CH2:33][CH2:32]3)=[C:3]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:4]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1参加物
4
反応条件
- 温度
- 120 °C
実験手順
Suspend 2 mmol (570 mg) of 6-chloro-5-benzyl-3-phenyl-1,2,4-triazine obtained in Step A of Example 57 in 40 ml of butanol, and add 4 equivalents of 1-(3-chlorophenyl)piperazine. Heat for 12 hours at 120° C., concentrate the solution, take up in ether, filter the resulting precipitate and recrystallise it from ethanol.