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Potassium Carbonate → Diethyl 2-bromo-2-(indol-4-yloxy)malonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Diethyl bromomalonate | HCID 69637 | — |
| 反応物 | 1H-indol-4-ol | HCID 75421 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Diethyl 2-(indol-4-yloxy)malonate | HCID 11608989 | 21% |
| 生成物 | Diethyl 2-bromo-2-(indol-4-yloxy)malonate | HCID 11639270 | 45% |
反応手順
A solution of 4-hydroxyindole (266 mg, 2 mmol) in acetone (20 mL) was cooled to 0° C. under nitrogen and anhydrous potassium carbonate (414 mg, 3 mmol) was added. A solution of commercial diethyl bromomalonate (92%; 520 mg, 2 mmol) in acetone (20 mL) was added dropwise. After stirring for 5 h at room temperature, more diethyl bromomalonate (92%; 520 mg) was added and the mixture was stirred at room temperature overnight. Work up and flash chromatography as above afforded 7 (360 mg, 45%) and 8 (123 mg, 21%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737169B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-048ee2c07d0f4ab183f06fcc23ac2876 |
| 出典メモ | uspto-grants-2010_06 |