2,2-Diethoxyethylamine → HCID 178467946、化合物

HRID 1656518ノート

反応式

HRID 1656518 の反応式
Cl.[F:2][C:3]1[CH:13]=[CH:12][C:6]([C:7](=[NH:11])OCC)=[CH:5][CH:4]=1.[CH2:14]([O:16][CH:17]([O:20][CH2:21][CH3:22])[CH2:18][NH2:19])[CH3:15]>C(O)C>[CH2:14]([O:16][CH:17]([O:20][CH2:21][CH3:22])[CH2:18][NH:19][C:7](=[NH:11])[C:6]1[CH:5]=[CH:4][C:3]([F:2])=[CH:13][CH:12]=1)[CH3:15]

参加物

4

反応物 2

HCID 695242,2-DiethoxyethylamineHCID 122821594-Fluorobenzimidic acid ethyl ester hydrochloride

生成物 1

HCID 178467946HCID 178467946、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 4-fluorobenzimidate hydrochloride (18.5 g) in ethanol (90 mL) at 0° C. was added aminoacetaldehyde diethyl acetal (14.5 mL) and the resulting solution was kept at 5° C. overnight. The solvent was evaporated, the resulting oil was dissolved in 1N sodium hydroxide (200 mL), and the solution was extracted with dichloromethane. The organic extracts were dried and evaporated to yield N-(2,2-diethoxyethyl)-4-fluorobenzamidine as an oil (21 g); MS: m/z=255(M+1).

後処理

  1. customThe solvent was evaporated
  2. dissolutionthe resulting oil was dissolved in 1N sodium hydroxide (200 mL)
  3. extractionthe solution was extracted with dichloromethane
  4. customThe organic extracts were dried
  5. customevaporated

出典と根拠

ORDレコード
ord-59f7e61c2cde4d8591621eb3cf94f238
出典データセット
uspto-grants-1993_10
特許番号
US05254558

反応ノート

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