Diethyl (ethoxymethylene)malonate → Ethyl 1-(2,2-diethoxyethyl)-2-(4-fluorophenyl)pyrimidin-6(1h)-one-5-carboxylate

反応式

C(O[CH:4]=[C:5]([C:11]([O:13]CC)=O)[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.[CH2:16]([O:18][CH:19]([O:31][CH2:32][CH3:33])[CH2:20][NH:21][C:22](=[NH:30])[C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1)[CH3:17]>>[CH2:16]([O:18][CH:19]([O:31][CH2:32][CH3:33])[CH2:20][N:21]1[C:11](=[O:13])[C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:30]=[C:22]1[C:23]1[CH:24]=[CH:25][C:26]([F:29])=[CH:27][CH:28]=1)[CH3:17]

参加物

反応物 2

HCID 6871Diethyl (ethoxymethylene)malonate

HCID 178467946HCID 178467946、化合物

生成物 1

HCID 18625664Ethyl 1-(2,2-diethoxyethyl)-2-(4-fluorophenyl)pyrimidin-6(1h)-one-5-carboxylate

実験手順

This compound was prepared from diethyl ethoxymethylenemalonate and N-(2,2-diethoxyethyl)-4-fluorobenzamidine by a procedure similar to that described in Example 1.b. to obtain ethyl 1-(2,2-diethoxyethyl)-2-(4-fluorophenyl)pyrimidin-6(1H)-one-5-carboxylate as an oil; MS: m/z=379(M+1).

出典と根拠

ORDレコード: ord-156e5853957d46cdb3b8ff913661c3b9
出典データセット: uspto-grants-1993_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05254558

反応ノート

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