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Potassium Carbonate → Diethyl 2-(indol-4-yloxy)malonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Diethyl bromomalonate | HCID 69637 | — |
| 反応物 | 1H-indol-4-ol | HCID 75421 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Diethyl 2-(indol-4-yloxy)malonate | HCID 11608989 | 34% |
| 生成物 | Diethyl 2-bromo-2-(indol-4-yloxy)malonate | HCID 11639270 | 13% |
反応手順
A solution of 4-hydroxyindole (266 mg, 2 mmol) in acetone (20 mL) was cooled to 0° C. under nitrogen and anhydrous potassium carbonate (414 mg, 3 mmol) was added. A solution of freshly distilled pure diethyl bromomalonate (574 mg, 2.4 mmol) in acetone (20 mL) was added dropwise and the mixture was stirred at room temperature overnight. Work up and flash chromatography as above afforded 7 (101 mg, 13%) and 8 (199 mg, 34%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737169B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-0c9a0cdfc8304382bf05447a70154c88 |
| 出典メモ | uspto-grants-2010_06 |