4-Hydroxy-1-phenyl-1,2-dihydroquinolin-2-one → 2-Aminotetralin

反応式

O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5](C)[C:4](=O)[CH:3]=1.O[C:15]1C2C(=CC=CC=2)N(CC)C(=O)C=1.OC1C2C(=CC=CC=2)N(CC=C)C(=O)C=1.OC1C2C(=CC=CC=2)N(C2C=CC=CC=2)C(=O)C=1>>[NH2:5][CH:4]1[CH2:3][CH2:2][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:15]1

参加物

反応物 4

HCID 546761614-Hydroxy-1-phenyl-1,2-dihydroquinolin-2-one

HCID 546846411-Ethyl-4-hydroxyquinolin-2(1H)-one

HCID 546864364-Hydroxy-N-methylcarbostyril

HCID 547196471-Allyl-4-hydroxy-2-oxo-1,2-dihydroquinoline

生成物 1

HCID 346772-Aminotetralin

実験手順

Following the procedure of Example 91, but starting from 4-hydroxy-1-methylcarbostyril, 4-hydroxy-1-ethylcarbostyril, 4-hydroxy-1-allylcarbostyril, or 4-hydroxy-1-phenylcarbostyril and reacting the raw chlorohydrin thus obtained with 2-aminotetralin, the following compounds are prepared respectively: