2-Bromobenzyl bromide → 1-Bromo-2-(methoxymethyl)benzene

HRID 1656704

反応式

HRID 1656704 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[CH3:10][O-:11].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][O:11][CH3:10]

参加物

4

反応物 2

HCID 769652-Bromobenzyl bromideHCID 10942334Sodium Methoxide

生成物 1

HCID 129271621-Bromo-2-(methoxymethyl)benzene収率 87%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

685 g (2.74 mol) of o-bromobenzyl bromide are refluxed together with 2.74 mol of a 30% strength sodium methylate solution in methanol for 15 hours. The mixture is cooled and then concentrated, the residue is taken up in ethyl acetate, and the solution is washed with water. The organic phase is dried over sodium sulfate and then concentrated. 478.2 g (87%) of product are obtained as a colorless liquid.

後処理

  1. temperatureThe mixture is cooled
  2. concentrationconcentrated
  3. washthe solution is washed with water
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-ac990156198e4b42a08f29931fbd0efa
出典データセット
uspto-grants-1993_10
特許番号
US05254717

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