関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Diethyl phenylmalonate | HCID 66514 | — |
| 反応物 | Potassium hydride | HCID 82127 | — |
| 反応物 | N-Fluorobenzenesulfonimide | HCID 588007 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Diethyl 2-fluoro-2-phenylmalonate | HCID 4246642 | 47% |
反応手順
1 millimole of diethyl phenylmalonate was stirred with potassium hydride in 2 milliliters ether for 30 minutes at -25° C. 1.2 molar equivalents N-fluorobenzenesulfonimide prepared according to Example 1 above in 2 milliliters ether were dropped into the mixture which was stirred for 1 hour at -20° C. The mixture was allowed to warm up to room temperature and water was added. The product was extracted into ether which was dried and evaporated. Purification was carried out on a silica gel column. C6H5CF(COOCH2CH3)2 was obtained in 47% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05254732 |
|---|
| 出典データセット | uspto-grants-1993_10 |
|---|
| ORD ID | ord-89ade536182d46b086d4d518e6d9e093 |
|---|
| 出典メモ | uspto-grants-1993_10 |
|---|
