Acetic Anhydride → 2-Formylamino-4-(4-formylaminophenylthiomethyl)thiazole

HRID 1656972ノート

反応式

HRID 1656972 の反応式
C(O[C:5](=[O:7])C)(=O)C.[CH:8]([NH:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][S:17][C:18]2[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=2)[N:15]=1)=[O:9]>C(O)=O>[CH:8]([NH:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][S:17][C:18]2[CH:23]=[CH:22][C:21]([NH:24][CH:5]=[O:7])=[CH:20][CH:19]=2)[N:15]=1)=[O:9]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 157291712-Formylamino-4-(4-aminophenylthiomethyl)thiazole

生成物 1

HCID 157291722-Formylamino-4-(4-formylaminophenylthiomethyl)thiazole収率 96.7%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

反応条件

温度
50 °C

実験手順

A mixture of acetic anhydride (1.84 g) and formic acid (0.9 g) was heated at 50° C. for 0.5 hours with stirring. The solution was cooled at room temperature and to the solution was added the 2-formylamino-4-(4-aminophenylthiomethyl)thiazole (1.6 g). The mixture was stirred at room temperature for 6.5 hours and then the mixture was poured into ice-water. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-formylamino-4-(4-formylaminophenylthiomethyl)thiazole (1.7 g, yield: 96.7%). mp: 195°-197° C. (dec.)

後処理

  1. temperatureThe solution was cooled at room temperature and to the solution
  2. stirringThe mixture was stirred at room temperature for 6.5 hours
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-e8bdc1367c2840b8a9a43c3d10efaff9
出典データセット
uspto-grants-1993_10
特許番号
US05256675

反応ノート

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