Hydrochloric Acid → 2-Amino-5-(4-hydroxyphenylthio)thiazole
反応式
C([NH:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)=[CH:8][N:9]=1)(=O)C.Cl>C(O)C>[NH2:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)=[CH:8][N:9]=1参加物
4
実験手順
A mixture of 2-acetylamino-5-(4-hydroxyphenylthio)thiazole (1.5 g) in a mixture of ethanol (40 ml) and aqueous 6N hydrochloric acid (6 ml) was refluxed for 4.5 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was dissolved in water. The solution was adjusted to pH 10 using aqueous sodium hydroxide under ice cooling. The precipitates were collected by filtration and recrystallized from a mixture of ethanol and water (3:1) to give 2-amino-5-(4-hydroxyphenylthio)thiazole (1.05 g, yield: 84.0%). mp: 187°-188° C.
後処理
- temperaturewas refluxed for 4.5 hours
- concentrationThe reaction mixture was concentrated under reduced pressure
- dissolutionthe residue was dissolved in water
- filtrationThe precipitates were collected by filtration
- customrecrystallized from a mixture of ethanol and water (3:1)
出典と根拠
- ORDレコード
- ord-42f8b7f420e045bf8712053badbcde08
- 出典データセット
- uspto-grants-1993_10
- 特許番号
- US05256675
反応ノート
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