Hydrochloric Acid → 2-amino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole

HRID 1656986ノート

反応式

HRID 1656986 の反応式
C([NH:4][C:5]1[S:6][C:7]([S:10][C:11]2[N:15]([CH3:16])[N:14]=[N:13][N:12]=2)=[CH:8][N:9]=1)(=O)C.Cl>C(O)C>[NH2:4][C:5]1[S:6][C:7]([S:10][C:11]2[N:15]([CH3:16])[N:14]=[N:13][N:12]=2)=[CH:8][N:9]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 157291852-acetylamino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole

生成物 1

HCID 157291862-amino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole収率 48.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-acetylamino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole (2.0 g) in a mixture of ethanol (20 ml) and aqueous 6N-hydrochloric acid (5 ml) was refluxed for 4 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was adjusted to pH 8 using aqueous sodium bicarbonate under ice cooling. The precipitates were collected by filtration, washed with water and the solid was recrystallized from ethanol to give 2-amino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole (0.81 g, yield: 48.5%). mp: 186°-188° C. (dec.)

後処理

  1. temperaturewas refluxed for 4 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water
  5. customthe solid was recrystallized from ethanol

出典と根拠

ORDレコード
ord-d4e50b2974d64392ac9c6cd44176fc69
出典データセット
uspto-grants-1993_10
特許番号
US05256675

反応ノート

読み込み中…