HCID 19786735、化合物 → HCID 57173485、化合物
反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH2:13])=[O:12])=[CH:8][CH:9]=2)[C:4]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][C:21](O)([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:20][CH2:19]2)=[CH:3]1>Cl>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH2:13])=[O:12])=[CH:8][CH:9]=2)[C:4]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]2[CH2:19][CH:20]=[C:21]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH2:22][CH2:23]2)=[CH:3]1参加物
3
実験手順
4.05 g of 1-methyl-3-[4-(4-hydroxy-4-phenyl-1-piperidyl)-butyl]-indole-5-carboxamide [obtainable by reacting 1-methyl-3-(4-bromobutyl)-indole-5carboxamide with 4-piperidone, followed by reaction with C6H5Li and hydrolysis] are heated at 50° with 40 ml of hydrochloric acid for 2 hours, and the mixture is worked up in the customary manner to give 1-methyl-3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)-butyl]-indole-5-carboxamide.
出典と根拠
- ORDレコード
- ord-4bfc641ab3d442d8836c9c856dfc9046
- 出典データセット
- uspto-grants-1993_10