Dimethylformamide dimethyl acetal → 3-Ethyl-5-(N-dimethylaminomethylenaminomethyl)-isoxazole
反応式
[NH2:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][CH3:9])[CH:4]=1.CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>>[CH2:8]([C:5]1[CH:4]=[C:3]([CH2:2][N:1]=[CH:12][N:13]([CH3:15])[CH3:14])[O:7][N:6]=1)[CH3:9]参加物
3
実験手順
9 g of 5-aminomethyl-3-ethyl-isoxazole is stirred in 12 ml of dimethylformamide-dimethylacetal with exclusion of moisture for 8 hours at 80° C. (bath temperature). After distillation on a bulb tube at 145° C. and 0.03 torr, 12.8 g (98% of theory) of the desired product is obtained.
後処理
- distillationAfter distillation on a bulb tube at 145° C.
出典と根拠
- ORDレコード
- ord-8819492e29704cdfa2819f613366d16d
- 出典データセット
- uspto-grants-1993_10
- 特許番号
- US05256682
反応ノート
読み込み中…