1-(3-Chlorophenyl)piperazine → 3-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one . dihydrochloride

HRID 1657405

反応式

HRID 1657405 の反応式
[Cl:1][CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[CH:11]=[CH:12][C:13]([CH3:15])=[CH:14][C:7]2=[N:6][C:5]=1[CH3:16].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[ClH:1].[ClH:17].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][C:4]3[C:9](=[O:10])[N:8]4[CH:11]=[CH:12][C:13]([CH3:15])=[CH:14][C:7]4=[N:6][C:5]=3[CH3:16])[CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1

参加物

4

反応物 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 1008613-(2-chloroethyl)-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

生成物 1

HCID 1317102643-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one . dihydrochloride収率 46.2%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 2.4 g of 3-(2-chloroethyl)-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one, 5.9 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed for 30 hours. After completion of the reaction, the rection mixture was then treated in the same manner as in Example 4, and the obtained crude crystals were recrystallized from a mixture of methanol and ethanol to give 2.2 g of the desired compound as pale yellow plates, m.p. 272° - 274°C (decomp.).

後処理

  1. temperaturewas refluxed for 30 hours
  2. customAfter completion of the reaction
  3. additionthe rection mixture was then treated in the same manner as in Example 4
  4. customthe obtained crude crystals
  5. customwere recrystallized from a mixture of methanol and ethanol

出典と根拠

ORDレコード
ord-6b7c1f244f27470ca6faeedfff4953db
出典データセット
uspto-grants-1976_06
特許番号
US03960863

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