1-(3-Chlorophenyl)piperazine → HCID 12414855、化合物

HRID 1657408

反応式

HRID 1657408 の反応式
[CH3:1][C:2]1[N:3]=[C:4]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:5]2[C:6](=[O:11])[C:7]=1[CH2:8][CH2:9]Cl.[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[N:3]=[C:4]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:5]2[C:6](=[O:11])[C:7]=1[CH2:8][CH2:9][N:27]1[CH2:26][CH2:25][N:24]([C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([Cl:17])[CH:19]=2)[CH2:29][CH2:28]1

参加物

4

反応物 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 124149402-methyl-3-(2-chloroethyl)-7-chloro-4H-pyrido[1,2-a]pyrimidin-4-one

生成物 1

HCID 12414855HCID 12414855、化合物収率 23.7%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 1.3 g of 2-methyl-3-(2-chloroethyl)-7-chloro-4H-pyrido[1,2-a]pyrimidin-4-one, 4.2 g of 1-(m-chlorophenyl)piperazine and 20 ml of toluene was refluxed with heating for 30 hours. After completion of the reaction, the reaction mixture was then treated in the same manner as in Example 8. The crude crystals thus obtained were recrystallized from ethanol to give 0.5 g of the desired compound as pale orangeyellow needles, m.p. 152° - 154°C.

後処理

  1. temperaturewas refluxed
  2. temperaturewith heating for 30 hours
  3. customAfter completion of the reaction
  4. additionthe reaction mixture was then treated in the same manner as in Example 8
  5. customThe crude crystals thus obtained
  6. customwere recrystallized from ethanol

出典と根拠

ORDレコード
ord-d081f29e65a146458b38aa8691e1d098
出典データセット
uspto-grants-1976_06
特許番号
US03960863

関連ノート

読み込み中…