1-(3-Chlorophenyl)piperazine → HCID 12414814、化合物

HRID 1657410ノート

反応式

HRID 1657410 の反応式
Cl[CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:7]2=[N:6][C:5]=1[CH3:16].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][C:4]3[C:9](=[O:10])[N:8]4[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:7]4=[N:6][C:5]=3[CH3:16])[CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1

参加物

4

反応物 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 124149363-(2-Chloroethyl)-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

生成物 1

HCID 12414814HCID 12414814、化合物収率 40.7%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 2.2 g of 3-(2-chloroethyl)-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one, 4.5 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed for 30 hours. After completion of the reaction, the reaction mixture was then treated in the same manner as in Example 10. The crude crystals thus obtained were recrystallized from a mixture of ethanol and n-hexane to give 1.5 g of the desired compound as pale yellow powders, m.p. 127° - 128°C.

後処理

  1. temperaturewas refluxed for 30 hours
  2. customAfter completion of the reaction
  3. additionthe reaction mixture was then treated in the same manner as in Example 10
  4. customThe crude crystals thus obtained
  5. customwere recrystallized from a mixture of ethanol and n-hexane

出典と根拠

ORDレコード
ord-10bcdedee62d4034959f8c27fc37583e
出典データセット
uspto-grants-1976_06
特許番号
US03960863

反応ノート

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