化工社化工社 化学情報印刷レポート · 研究参考用
Phosphonic acid → N-methylpyrrolidone-5,5-diphosphonic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphonic acid | HCID 407 | — |
| 反応物 | Phosphorus trichloride | HCID 24387 | — |
| 反応物 | 3-(Methylcarbamoyl)propanoic acid | HCID 292050 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-methylpyrrolidone-5,5-diphosphonic acid | HCID 12886162 | — |
反応手順
28.5 gm of succinic acid monomethylamide (0.216 mol) were melted with 35.4 gm of H3PO3 (0.432 mol) at 70°C and then slowly mixed with 37.8 ml of PCl3 (0.432 mol). After an additional 5 hours at 70°C, the product was hydrolyzed with 300 ml of H2O. Filtration with activated carbon at the boiling point yielded a clear solution from which the N-methylpyrrolidone-5,5-diphosphonic acid was precipitated with ethanol and acetone. Crude yield 4.2 gm (7% of the theory).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03960888 |
| 出典データセット | uspto-grants-1976_06 |
| ORD ID | ord-03c27f84e5744cf1996243df3e845b70 |
| 出典メモ | uspto-grants-1976_06 |