(E)-2-Nonenoic Acid → 2-Nonen-1-ol, (2E)-

HRID 1657944ノート

反応式

HRID 1657944 の反応式
[H-].[H-].[H-].[H-].[Li+].[Al+3].[C:7](O)(=[O:16])/[CH:8]=[CH:9]/[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>CCOCC>[CH2:7]([OH:16])/[CH:8]=[CH:9]/[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

参加物

4

反応物 2

HCID 5312586(E)-2-Nonenoic AcidHCID 21226445Aluminium lithium hydride

生成物 1

HCID 53649412-Nonen-1-ol, (2E)-

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A 500 ml flask with a reflux condenser, mechanical stirrer and a dropping funnel, and protected from moisture with a drying tube is charged with LiAlH4 (6.1 g, 0.16 mole) and 200 ml ether. A solution of trans-2-nonenoic acid (7.8 g, 0.05 mole) in 25 ml ether is added at a rate to maintain refluxing. Refluxing is continued for 1 hour and the mixture cooled. Exess reagent is destroyed by the addition of ethyl acetate (5 ml) followed by acidification with 5M HCl. The organic layer is separated, washed with water, dried and distilled under vacuum to give trans-2-nonenol.

後処理

  1. customA 500 ml flask with a reflux condenser, mechanical stirrer and a dropping funnel, and protected from moisture with a drying tube
  2. temperatureto maintain
  3. temperaturerefluxing
  4. temperatureRefluxing
  5. temperaturethe mixture cooled
  6. customExess reagent is destroyed by the addition of ethyl acetate (5 ml)
  7. customThe organic layer is separated
  8. washwashed with water
  9. customdried
  10. distillationdistilled under vacuum

出典と根拠

ORDレコード
ord-885c5416208049a48577fb256c5ab3b5
出典データセット
uspto-grants-1976_06
特許番号
US03962321

反応ノート

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