Diphenyl Ether → HCID 12223713、化合物
反応式
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:16]=[C:15]2[C:6]([S:7][C:8]3[CH:9]=[CH:10][CH:11]=[C:12]([C:17]([N:19]=[C:20]=[S:21])=[O:18])[C:13]=3[NH:14]2)=[CH:5][CH:4]=1.C1(OC2C=CC=CC=2)C=CC=CC=1>C1(C)C=CC=CC=1>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[CH:5][C:6]2[S:7][C:8]3[C:13]4=[C:12]([C:17](=[O:18])[NH:19][C:20](=[S:21])[N:14]4[C:15]=2[CH:16]=1)[CH:11]=[CH:10][CH:9]=3参加物
4
実験手順
A slurry of 53.7 g. (0.168 mol.) of 8-trifluoromethylphenothiazine-1-carboxylic acid isothiocyanate in 30 ml. of diphenyl ether was heated in an oil bath at 210° for one hour. The reaction mixture first became a homogenous liquid and then turned into a solid mass. The cooled reaction mixture was refluxed for several minutes in 100 ml. of toluene, cooled to ambient temperature, and the insoluble material was collected by filtration and washed with several small portions of toluene to give the title compound, m.p. 297°-299° (ethanol).