Ethanol → Potassium 8-ethyl-5,8-dihydro-5-oxo-2-(piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylate

反応式

C(=O)([O-])[O-].[K+:5].[K+].[CH2:7]([N:9]1[C:14]2[N:15]=[C:16]([N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[N:17]=[CH:18][C:13]=2[C:12](=[O:25])[C:11]([C:26]([OH:28])=[O:27])=[CH:10]1)[CH3:8].C(O)C>O>[CH2:7]([N:9]1[C:14]2[N:15]=[C:16]([N:19]3[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]3)[N:17]=[CH:18][C:13]=2[C:12](=[O:25])[C:11]([C:26]([O-:28])=[O:27])=[CH:10]1)[CH3:8].[K+:5]

参加物

実験手順

To a solution of potassium carbonate (2.76 g) in 60 ml of water was added 6.06 g of 5,8-dihydro-8-ethyl-2-(1-piperazinyl)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid. The resulting mixture was heated on a steam bath until it became a clear solution. Ethanol was added to the solution, and the mixture was then kept below room temperature by external cooling to yield the precipitate, which was collected and washed with ethanol. There is obtained 4.2 g of the product m.p. above 300°C.