NaNCO → N-(2,3-Dihydro-1-benzofuran-5-yl)-N-propan-2-ylurea

HRID 1658283ノート

反応式

HRID 1658283 の反応式
[CH:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]2[O:12][CH2:11][CH2:10][C:9]=2[CH:13]=1)([CH3:3])[CH3:2].[N-:14]=[C:15]=[O:16].[Na+]>C(O)(=O)C>[CH:1]([N:4]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][CH2:11][CH2:10][C:9]=2[CH:13]=1)[C:15]([NH2:14])=[O:16])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 11051568NaNCOHCID 21529005N-isopropyl-2,3-dihydro-5-benzofuranamine

生成物 1

HCID 21529015N-(2,3-Dihydro-1-benzofuran-5-yl)-N-propan-2-ylurea

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 14.2 g. of N-isopropyl-2,3-dihydro-5-benzofuranamine in 300 ml. of glacial acetic acid, cooled to 15°±5°C. is added 4.9 g. of sodium isocyanate. The mixture is stirred at room temperature for 18 hours and then concentrated in vacuo. The residue is treated with 200 ml. of 2N sodium hydroxide solution and then extracted twice with chloroform. The combined chloroform extracts are dried with anhydrous magnesium fulfate, filtered and concentrated in vacuo to obtain an oil of 1-isopropyl-1-(2,3-dihydro-5-benzofuranyl)urea.

後処理

  1. additionis added 4.9 g
  2. concentrationconcentrated in vacuo
  3. additionThe residue is treated with 200 ml
  4. extractionof 2N sodium hydroxide solution and then extracted twice with chloroform
  5. dry with materialThe combined chloroform extracts are dried with anhydrous magnesium fulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-fbe4d884e36d4e7abed926bfcffcb84c
出典データセット
uspto-grants-1976_06
特許番号
US03963717

反応ノート

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