Methanol → N-isopropyl-2,3-dihydro-6-benzofuranamine

HRID 1658285ノート

反応式

HRID 1658285 の反応式
[O:1]1[C:5]2[CH:6]=[C:7]([NH2:10])[CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.CO.[CH:13](I)([CH3:15])[CH3:14]>C(N(CC)CC)C>[CH:13]([NH:10][C:7]1[CH:8]=[CH:9][C:4]2[CH2:3][CH2:2][O:1][C:5]=2[CH:6]=1)([CH3:15])[CH3:14]

参加物

5

反応物 3

HCID 887MethanolHCID 6362Isopropyl iodideHCID 123690442,3-Dihydro-1-benzofuran-6-amine

生成物 1

HCID 21528943N-isopropyl-2,3-dihydro-6-benzofuranamine

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

To a solution of 2.8 g. of 2,3-dihydro-6-benzofuranamine in 150 ml. of methanol is added 18 ml. of isopropyl iodide and 26.5 ml. of triethylamine. The solution is refluxed for 60 hours and then concentrated in vacuo. The resultant oil is extracted repeatedly with diethyl ether. The extracts are combined, filtered through Celite, and the ether removed in vacuo to give an oil of N-isopropyl-2,3-dihydro-6-benzofuranamine.

後処理

  1. temperatureThe solution is refluxed for 60 hours
  2. concentrationconcentrated in vacuo
  3. extractionThe resultant oil is extracted repeatedly with diethyl ether
  4. filtrationfiltered through Celite
  5. customthe ether removed in vacuo

出典と根拠

ORDレコード
ord-a51d9ac27980474b8dd4ba0d8f526425
出典データセット
uspto-grants-1976_06
特許番号
US03963717

反応ノート

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