Methanol → N-isopropyl-2,3-dihydro-7-benzofuranamine

HRID 1658289ノート

反応式

HRID 1658289 の反応式
[O:1]1[C:5]2[C:6]([NH2:10])=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.CO.[CH:13](I)([CH3:15])[CH3:14]>C(N(CC)CC)C>[CH:13]([NH:10][C:6]1[C:5]2[O:1][CH2:2][CH2:3][C:4]=2[CH:9]=[CH:8][CH:7]=1)([CH3:15])[CH3:14]

参加物

5

反応物 3

HCID 887MethanolHCID 6362Isopropyl iodideHCID 128059502,3-Dihydro-1-benzofuran-7-amine

生成物 1

HCID 21528960N-isopropyl-2,3-dihydro-7-benzofuranamine

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

To a solution of 15 g. of 2,3-dihydro-7-benzofuranamine in 150 ml. of methanol is added 8.5 ml. of isopropyl iodide and 13.4 ml. of triethylamine. The solution is refluxed for 45 hours and then concentrated in vacuo. The resulting oil is extracted several times with diethyl ether, the ether extracted combined filtered through Celite, and the ether removed in vacuo to obtain an oil of N-isopropyl-2,3-dihydro-7-benzofuranamine.

後処理

  1. temperatureThe solution is refluxed for 45 hours
  2. concentrationconcentrated in vacuo
  3. extractionThe resulting oil is extracted several times with diethyl ether
  4. extractionthe ether extracted
  5. filtrationcombined filtered through Celite
  6. customthe ether removed in vacuo

出典と根拠

ORDレコード
ord-a1faca4a36954c76af9ae6b1b10ea945
出典データセット
uspto-grants-1976_06
特許番号
US03963717

反応ノート

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