Acetic Anhydride → 3-Bromopyridine-2-carbonitrile

HRID 1658321ノート

反応式

HRID 1658321 の反応式
[Br:1][C:2]1[C:3]([C:8]([NH2:10])=O)=[N:4][CH:5]=[CH:6][CH:7]=1.C(OC(=O)C)(=O)C>>[Br:1][C:2]1[C:3]([C:8]#[N:10])=[N:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 215291573-Bromopicolinamide

生成物 1

HCID 8176943-Bromopyridine-2-carbonitrile

実験手順

3-Bromopicolinamide, prepared as in Example 2(4 g.) is heated with 100 ml. of acetic anhydride on a steam bath. The mixture is then concentrated and worked up by diluting and triturating with water. The solid is dried and sublimed to give 3-bromopicolinonitrile.

後処理

  1. temperatureis heated with 100 ml
  2. concentrationThe mixture is then concentrated
  3. additionby diluting
  4. customtriturating with water
  5. customThe solid is dried

出典と根拠

ORDレコード
ord-9e679648ec20451fb4ef3e09cf16088a
出典データセット
uspto-grants-1976_06
特許番号
US03963733

反応ノート

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