化工社化工社 化学情報印刷レポート · 研究参考用
3-Trifluoromethylisobutyranilide → Ethyl-N-(3-trifluoromethylphenyl)isobutyrimidate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Trifluoromethylisobutyranilide | HCID 137264 | — |
| 反応物 | Triethyloxonium tetrafluoroborate | HCID 2723982 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Ethyl-N-(3-trifluoromethylphenyl)isobutyrimidate | HCID 21528116 | — |
反応手順
Add a solution of 5.0 g. (0.03 moles) of triethyloxonium fluoborate in 13 ml. of dichloromethane to a solution of 7.3 g. (0.03 moles) of 3'-trifluoromethylisobutyranilide in 60 ml. of dichloromethane and reflux for 20 hours. Remove 50 ml. of dichloromethane and add 150 ml. of dry ether to precipitate out the product of this example as its fluoborate salt, m.p.=95°-100°C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03965176 |
| 出典データセット | uspto-grants-1976_06 |
| ORD ID | ord-9ca430cf61254486bff17b0e0f712086 |
| 出典メモ | uspto-grants-1976_06 |