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Diethyl (ethoxymethylene)malonate → [[[1-(2-Furyl)methyl-5-pyrazolyl]amino]methylene]malonic acid diethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 反応物 | 1-(furan-2-ylmethyl)-1H-pyrazol-5-amine | HCID 2546182 | — |
| 生成物 | [[[1-(2-Furyl)methyl-5-pyrazolyl]amino]methylene]malonic acid diethyl ester | HCID 68131587 | — |
反応手順
163 g of 1-(2-furyl)methyl-5-aminopyrazole (1 mol) and 216 g of ethoxymethylene malonic acid diethyl ester (1 mol) are heated to 130° (bath temperature) until the theoretical amount of alcohol is distilled off. The remaining oil, [[[1-(2-furyl)methyl-5-pyrazolyl]amino]methylene]malonic acid diethyl ester, is recrystallized from methanol, yield 280 g (84%), m.p. 84°-86 °.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03966746 |
| 出典データセット | uspto-grants-1976_06 |
| ORD ID | ord-1195c40a25384f9793d69313ad4e4d52 |
| 出典メモ | uspto-grants-1976_06 |