Sulfuric Acid → 1-Chloro-4-[2,2,2-trichloro-1-(4-chlorophenoxy)ethyl]benzene

HRID 1658978ノート

反応式

HRID 1658978 の反応式
[Cl:1][C:2]([Cl:13])([Cl:12])[CH:3]([OH:11])[C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][CH:5]=1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18](O)=[CH:17][CH:16]=1.S(=O)(=O)(O)O>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([O:11][CH:3]([C:2]([Cl:1])([Cl:12])[Cl:13])[C:4]2[CH:5]=[CH:6][C:7]([Cl:10])=[CH:8][CH:9]=2)=[CH:17][CH:16]=1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 46844-ChlorophenolHCID 214174-Chloro-alpha-(trichloromethyl)benzenemethanol

生成物 1

HCID 215268891-Chloro-4-[2,2,2-trichloro-1-(4-chlorophenoxy)ethyl]benzene

実験手順

α-trichloromethyl-p-chlorobenzyl alcohol, 5.0g, was stirred with p-chlorophenol, 2.6g, and sulfuric acid, 35 ml, was added dropwise. After 2 hrs. of stirring, the mixture was poured onto ice and extracted with ether. After drying with sodium sulfate, the ether was removed under vacuum and the residue was recrystallized from ethanol to give α-trichloromethyl-p-chlorobenzyl p-chlorophenyl ether, mp 101°C. This method of synthesis is referred to in Table I as method A.

後処理

  1. additionwas added dropwise
  2. additionthe mixture was poured onto ice
  3. extractionextracted with ether
  4. dry with materialAfter drying with sodium sulfate
  5. customthe ether was removed under vacuum
  6. customthe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-606723cb101542fcac09f8013b72e1f1
出典データセット
uspto-grants-1976_06
特許番号
US03966824

反応ノート

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