Methyl Isocyanate → 3-Isopropyl-2-[O-(methylcarbamoyl) oximino]-4-thiazolidinone
反応式
[CH:1]([N:4]1[C:8](=[O:9])[CH2:7][S:6][C:5]1=[N:10][OH:11])([CH3:3])[CH3:2].[CH3:12][N:13]=[C:14]=[O:15]>CC(C)=O.C(#N)C.C(N(CC)CC)C>[CH:1]([N:4]1[C:8](=[O:9])[CH2:7][S:6][C:5]1=[N:10][O:11][C:14](=[O:15])[NH:13][CH3:12])([CH3:3])[CH3:2]参加物
5
実験手順
To a solution of 1.0 g of 3-isopropyl-2-oximino-4-thiazolidinone in 50 ml acetone-acetonitrile solution (1:1) was added 1 ml of methylisocyanate and 5 drops of triethylamine. The reaction mixture was placed in a pressure bottle and left overnight at ambient temperature. After concentrating under vacuo the residual oil was diluted with diethylether. On cooling the product crystallized. Recrystallized from ethyl ether. Weight 1.8 g. m.p. 94°-96°C.
後処理
- concentrationAfter concentrating under vacuo the residual oil
- additionwas diluted with diethylether
- temperatureOn cooling the product
- customcrystallized
- customRecrystallized from ethyl ether
出典と根拠
- ORDレコード
- ord-a617895ddbfa447f9667cda27f19deeb
- 出典データセット
- uspto-grants-1976_06
- 特許番号
- US03966953
反応ノート
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